3,962 research outputs found

    Particle interactions and lattice dynamics: Scenarios for efficient bidirectional stochastic transport?

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    Intracellular transport processes driven by molecular motors can be described by stochastic lattice models of self-driven particles. Here we focus on bidirectional transport models excluding the exchange of particles on the same track. We explore the possibility to have efficient transport in these systems. One possibility would be to have appropriate interactions between the various motors' species, so as to form lanes. However, we show that the lane formation mechanism based on modified attachment/detachment rates as it was proposed previously is not necessarily connected to an efficient transport state and is suppressed when the diffusivity of unbound particles is finite. We propose another interaction mechanism based on obstacle avoidance that allows to have lane formation for limited diffusion. Besides, we had shown in a separate paper that the dynamics of the lattice itself could be a key ingredient for the efficiency of bidirectional transport. Here we show that lattice dynamics and interactions can both contribute in a cooperative way to the efficiency of transport. In particular, lattice dynamics can decrease the interaction threshold beyond which lanes form. Lattice dynamics may also enhance the transport capacity of the system even when lane formation is suppressed.Comment: 25 pages, 17 figures, 2 table

    Measurements of the effect of boundary conditions on upstream and downstream noise arising from entropy spots

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    Pressure fluctuations in combustors arise either directly from the heat release rate perturbations of the flame (direct noise), or indirectly from the acceleration of entropy, vorticity or compositional perturbations through nozzles or turbine guide vanes (indirect noise). In this work, the generation of synthetic entropy spots via the Joule effect produces direct noise, and their acceleration through orifice plates and nozzles produces indirect noise. These acoustic waves reverberate, reflecting several times at the boundaries to add up to the measured pressure. Single travelling pulses are isolated by the introduction of a semiinfinite tube that acts as an anechoic termination for a limited time-window. It is shown how the shape of the converging nozzle does not affect the reflection of the direct noise wave, confirming the hypothesis of a compact nozzle. Further, it is demonstrated that the assumption of an isentropic nozzle does not hold, but that an alternative theory which takes into account the partial acoustic energy dissipation offers good agreement with the experiments. Finally, it is shown that the reflected indirect noise is underpredicted by isentropic theories. An extension of the present work is indicated for the measurement of the transmissivity of indirect noise.Francesca De Domenico is supported by the Honorary Vice-Chancellor’s Award and a Qualcomm/DTA Studentship (University of Cambridge). Erwan Rolland is supported by an EPSRC DTA studentship (University of Cambridge). Experiments were partly funded by EPSRC grant EP/K02924X/1

    Administrative Law

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    This is the author accepted manuscript. The final version is available from Oxford University Press via the link in this recor

    Weight loss and ethnicity: a cohort study of the effects induced by a very low calorie diet.

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    We aimed to determine whether British Asians of Indian or Pakistani descent differed in their baseline characteristics and in response to a twelve-week, very-low-calorie diet (VLCD). We then assessed whether or not a VLCD had a different effect on Asians and Caucasians, in terms of changes in weight and waist circumference. Weight loss was achieved using a nutritionally-complete VLCD with an average daily intake of 550kcal, using greater than or equal to 50g protein, greater than or equal to 50g carbohydrate, mean 15.9g fats, and greater than or equal to 100% of the recommended daily allowances (RDA) for key vitamins and minerals. The VLCD was used alongside a unique behaviour-change programme, called LighterLife (LL). Data were analysed for Asians who were recruited onto LL in 2009/2010, and for whom twelve-week weight change information was available. Waist circumference data were available for a subset of Asians, including age, body mass index and gender. These were matched to a Caucasian population and compared by independent t-test. No differences were observed between the Indian and Pakistani group for baseline measurements or weight change at twelve weeks. Caucasians had a greater percent excess body weight loss (%EBWL) than Asians at twelve weeks (72.4 ± 22.1 vs 48.9 ± 18.0, p < 0.0001). However, Asians had a greater waist circumference reduction per kilogram of weight loss when compared to Caucasians (1.16 ± 0.7 vs 0.95 ± 0.3, p = 0.037). It appears that, despite a greater %EBWL for Caucasians, Asians had a greater waist circumference reduction per kilogram of weight loss using a VLCD approach for a twelve-week period

    Chaotic properties of systems with Markov dynamics

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    We present a general approach for computing the dynamic partition function of a continuous-time Markov process. The Ruelle topological pressure is identified with the large deviation function of a physical observable. We construct for the first time a corresponding finite Kolmogorov-Sinai entropy for these processes. Then, as an example, the latter is computed for a symmetric exclusion process. We further present the first exact calculation of the topological pressure for an N-body stochastic interacting system, namely an infinite-range Ising model endowed with spin-flip dynamics. Expressions for the Kolmogorov-Sinai and the topological entropies follow.Comment: 4 pages, to appear in the Physical Review Letter
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